Investigations on Tuberculin

Studies on Tuberculin Fever

In a search for the source of the circulating endogenous pyrogen (EP) that mediates tuberculin-induced fever, tuberculin was incubated in vitro with various tissues of rabbits sensitized by intravenous infection with BCG. Evidence was obtained that tuberculin specifically stimulates cells in the blood of sensitized rabbits to generate pyrogen in vitro, whereas both lymph node and spleen cells f...

Potential consequences of using Aplisol tuberculin tests in prior epidemic investigations.

To the Editor: Several reports, including one by Shands et al (Infect Control Hosp Epidemiol 1994;15:758-760), indicate an apparent widespread high falsepositive rate associated with the use of Aplisol (Parke-Davis) tuberculin material.lj Numerous other reports indicate that this problem is not recent.2-5 To date, investigators have emphasized the cost and increased frequency of false-positive ...

Tuberculin in Ophthalmology Tuberculin in Ophthalmology

Tuberculin Test

  در ایالات متحده حدود ۱۵ میلیون نفر آلوده به میکروب سل می باشند و هر سال ۳۰ هزار مورد جدید گزارش می شود. انتظار می رود تا سال ۲۰۰۰ این رقم به ۵۰۰۰۰ نفر در سال برسد. تست مانتو نسبت به تست چند سوزنی که قبلاً بسیار متداول بود، بمراتب دقیق تر است و بهمین دلیل به عنوان یک روش انتخابی برای غربالگری سل شناخته شده است. امروزه این تست اولین اقدام برای اثبات عفونت کلینیکی بوده و در صورتی که بطور دقیق ا...

B.C.G. tuberculin.

It is well known that after Bacille Calmette-Gue'rin (B.C.G.) vaccination the degree of allergy as shown by the tuberculin test is of a lesser order than that after infection with virulent tubercle bacilli. For this reason it may be necessary to perform several successively stronger tuberculin tests up to 100 units of old tuberculin (Mantoux 1/100) before a positive post-vaccination test is obt...